The world of aesthetic treatments is constantly evolving, offering incredible non-surgical options to rejuvenate and restore skin health. Gone are the days when injectables were only about adding volume; today, the focus is on bio-remodelling and cellular regeneration.
If you’ve been looking to combat dullness, laxity, and fine lines, you’ve likely heard the buzz around treatments like Profhilo, Jalupro, and the exciting new class of Polynucleotides. But with so many options, how do you choose the one that’s right for your skin goals?
The difference lies not just in their catchy names, but in their core ingredients and the fundamental way they work with your body’s natural processes.
- Hyaluronic Acid (HA) Boosters (like Profhilo and Jalupro) are hydration powerhouses, using HA combined with essential nutrients (like Amino Acids) to plump, smooth, and boost collagen production.
- Polynucleotides are the cutting-edge regenerative option, working at a DNA level to signal cells to repair, regenerate, and strengthen tissue from the inside out.
Choosing the right treatment depends on whether your priority is immediate hydration, structural support, or deep cellular repair.
To help you decode the science and select your perfect skin cocktail, we’ve broken down the key differences between the leading treatments in one easy-to-read comparison table:
| Category | Polynucleotides | Jalupro HMW | Jalupro Super Hydro | Profhilo |
|---|---|---|---|---|
| Main Ingredient | Purified DNA fragments (from salmon/trout) | Hyaluronic Acid + Amino Acids | Hyaluronic Acid + 7 Amino Acids & 3 Peptides | High concentration of pure Hyaluronic Acid |
| Action | Deep regeneration activates fibroblasts and improves cell repair | Hydrates & stimulates collagen via fibroblast activation | Multi-level hydration, structural support & ligament regeneration | Bio-remodelling, hydrates & minimally stimulates collagen & elastin |
| Results | Gradual – full effect after the final session (6–8 weeks) | Faster-acting (initial effects within 5–7 days) | Quicker visible hydration and deeper collagen regeneration | Moderate – hydration/plumping visible within 4 weeks |
| Best For | Scarring, mild laxity, under-eye hollowing, rosacea-prone skin | Fine lines, mild to moderate laxity, general skin quality boost | Mild to deep volume loss, sagging, advanced skin ageing (firming & restructuring) | Skin laxity, dullness, fine lines (best for global hydration & mild tightening) |
| Amount of treatments | 3–4 sessions, 2–3 weeks apart | 2–4 sessions | 3–4 sessions, 4 weeks apart | 2 sessions, 4 weeks apart |
| Highlights | Focuses on deep cellular repair and regeneration | Combines hydration with collagen-boosting Amino Acids | Provides volume support, deepest regeneration, and structural support | Excellent for global hydration with minimal downtime |
Ready to find out which booster is the best match for your unique skin? Book a consultation with a specialist today to discuss your goals and create a custom-tailored treatment plan!


