Polynucleotides

Introduction

Polynucleotides are injectable bio-stimulators derived from purified DNA fragments, typically from fish, that promote skin rejuvenation and tissue regeneration. They are a cutting-edge treatment that can help rejuvenate your skin. This innovative therapy involves injecting purified Salmon DNA fragments to stimulate collagen production, improve skin elasticity, and reduce the appearance of fine lines and wrinkles.

About the treatment

Polynucleotide injections work by stimulating the body’s natural healing processes. The injected DNA fragments trigger collagen production, which helps to improve skin firmness and reduce wrinkles. They also accelerate tissue repair, which can help to minimise the appearance of scars and other skin imperfections.

Additionally, polynucleotides can enhance skin hydration, improving the overall appearance of your skin. By reducing inflammation, they can also soothe irritated skin.

Benefits, results and expected outcomes

Improved skin texture and tone: Polynucleotides can help to improve the overall appearance of your skin.

Reduced wrinkles and fine lines: This treatment can help to minimise the appearance of wrinkles and fine lines.

Minimised scarring: Polynucleotides can help to reduce the appearance of scars, including acne scars.

Increased skin hydration: This treatment can help to improve your skin’s moisture levels.

Please note: It’s important to consult with a qualified medical professional to determine if polynucleotide treatment is right for you.

Pricing

As with all our injectables products, prices depend on your consultation and what goals you’re looking to achieve. Prices for Polynucleotides start from £300 per session when purchased as a course.

Book a consultation

Meet with our clinical team to discuss further

Book now

Session Duration

30 mins

Session Frequency

4 weeks apart

Comfort Level

Mild discomfort

Number of Sessions

From 3

Polynucleotides – Frequently Asked Questions

Can I have Polynucleotides Injections if I am allergic to fish?

Yes you can as Polynucleotides are not made from fish themselves but from fish (specifically salmon and trout) DNA. There have been no reports within the industry of allergic reactions in people with fish allergies.

Who is suitable for Polynucleotide treatment?

Most people will benefit from polynucleotide treatment but in older skin the benefits are more noticeable. This is because of the depletion of collagen and elastin causing signs of ageing. The stimulation of collagen production and cell repair and renewal helps to reduce this and gives the skin a refreshed and rejuvenated appearance.

What is the difference between Profhilo and Polynucleotides?

Profhilo is a hyaluronic acid injection which deeply hydrates the skin giving an overall glow. Very appropriate for boosting younger skins. It doesn’t however address the common signs of ageing. Polynucleotides energise the fibroblast cells which produce collagen. This helps to remodel the skin and improve many of the signs of ageing.

What is the downtime after Polynucleotides Injections?

As the skin is being injected in multiple areas, small bumps or red marks may appear and can last for a few days following treatment. As with any injectable treatment, there is a risk of redness, swelling and bruising.

When will I see results?

For optimal results, typically 3 treatments are required. Many patients begin to notice subtle enhancements in skin texture and hydration within the first few weeks post-treatment. These early changes are indicative of the treatment initiating its regenerative effects at the cellular level. The most significant results typically manifest around the 12-week mark. By this time, the cumulative effects of increased collagen and elastin production lead to smoother, brighter, and more lifted skin.

This gradual transformation aligns with the body’s natural regenerative processes, ensuring a more sustainable and natural-looking outcome.

Skin boosters and injectables – compare your options

Category	Polynucleotides	Jalupro HMW	Jalupro Super Hydro	Profhilo
Main Ingredient	Purified DNA fragments (from salmon/trout)	Hyaluronic Acid + Amino Acids	Hyaluronic Acid + 7 Amino Acids & 3 Peptides	High concentration of pure Hyaluronic Acid
Action	Deep regeneration, activates fibroblasts, improves cell repair	Hydrates & stimulates collagen via fibroblast activation	Multi-level hydration, structural support & ligament regeneration	Bio-remodelling, hydrates & minimally stimulates collagen & elastin
Results	Gradual – full effect after the final session (6–8 weeks)	Faster-acting (initial effects within 5–7 days)	Quicker visible hydration and deeper collagen regeneration	Moderate – hydration/plumping visible within 4 weeks
Best For	Scarring, mild laxity, under-eye hollowing, rosacea-prone skin	Fine lines, mild to moderate laxity, general skin quality boost	Mild to deep volume loss, sagging, advanced skin ageing (firming & restructuring)	Skin laxity, dullness, fine lines (best for global hydration & mild tightening)
Amount of treatments	3–4 sessions, 2–3 weeks apart	2–4 sessions	3–4 sessions, 4 weeks apart	2 sessions, 4 weeks apart
Highlights	Focuses on deep cellular repair and regeneration	Combines hydration with collagen-boosting Amino Acids	Provides volume support, deepest regeneration, and structural support	Excellent for global hydration with minimal downtime

What our customers say about Polynucleotides

★★★★★

Super professional, always considerate and attentive to the client needs. Careful practitioner with clear instructions and ample explanation of what the procedure involves. Whilst realistically managing expectations, Kamila is not forgetting to mention other options with pros and cons. Quite happy with the results so far, thank you!

★★★★★

Great personal treatment. Dr Kasim takes time with my treatment providing full explanations. I have every confidence in him. He has an excellent bedside manner.